Product Description: pre-mRNA-processing factor 40, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.37 | 0.82 |
| Trophozoite | expressed | 0.53 | 0.70 |
| Schizont | expressed | 0.11 | 0.94 |
| Gametocyte | expressed | 0.40 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1316500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.597 | MFS: -2.533 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8A8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101966
Most Similar Human Ortholog: H0YII7
TM-align score: 0.69 | RMSD: 2.96
Seq Identity: 0.14 | Length: 123 / 906
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000110844 | pre-mRNA processing factor 40 homolog B |
| ENSG00000196504 | pre-mRNA processing factor 40 homolog A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 37 | 18 | 60 |
| disruptive | 18 | 121 | 57 | 162 |
| missense | 10 | 102 | 46 | 137 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 70 | 32 | 61 |
| disruptive | 39 | 256 | 116 | 230 |
| missense | 23 | 204 | 94 | 157 |
PlasmoDB Total SNPs: 203
Non-coding: 95 | Synonymous: 65 | Nonsynonymous: 43 | Stop Codon: 0
Protein Length: 906 | Molecular Weight (kDa): 106.123
UniProt ID(s): A0A5K1K8A8
PDB ID(s): None
Isoelectric Point: 8.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001202 | WW domain |
| InterPro | IPR002713 | FF domain |
| InterPro | IPR036020 | WW domain superfamily |
| InterPro | IPR036517 | FF domain superfamily |
| InterPro | IPR039726 | Pre-mRNA-processing factor Prp40 |
| PFam | PF00397 | WW domain |
| PFam | PF01846 | FF domain |
| Superfamily | SSF51045 | WW domain superfamily |
| Superfamily | SSF81698 | FF domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22287628 | Structure-function analysis and genetic interactions of the yeast branchpointbinding protein Msl5 | Chang J, Schwer B, Shuman S | 10.1093/nar/gks049 |
| 19722265 | Solution structure of the fourth FF domain of yeast Prp40 splicing factor | Bonet R, Ruiz L, Morales B, Macias MJ | 10.1002/prot.22547 |
| 38168357 | Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNAsplicing and mitochondrial dysfunction in the budding yeast | Chalivendra S, Shi S, ..., Zhao R | 10.1101/2023.12.15.571893 |