PF3D7_1316700

Genome location: Pf3D7_13_v3:695,732..697,985(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MNMNLVLFISLICLFFGCSNKLYA

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	1.00
Schizont	not expressed	0.01	0.99
Gametocyte	expressed	0.26	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1316700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.721 | MFS: -2.79 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Q0

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.62) with 3MCO (Global RMSD=22.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532816

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	40	19	52
disruptive	10	71	40	87
missense	9	70	37	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	72	43	45
disruptive	18	135	61	149
missense	15	126	55	136

PlasmoDB Total SNPs: 51

Non-coding: 21 | Synonymous: 13 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 623 | Molecular Weight (kDa): 73.388

UniProt ID(s): A0A5K1K8Q0

PDB ID(s): None

Isoelectric Point: 7.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
PFam	N/A	N/A
Superfamily	SSF49899	Concanavalin A-like lectin/glucanase domain superfamily