About Gene List

PF3D7_1316800 (SEC20)

Genome location: Pf3D7_13_v3:697,830..700,357(-)

Genome classification: Core

Function and Localization

Product Description: protein transport protein SEC20, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.22 0.89
Trophozoite expressed 0.42 0.74
Schizont expressed 0.14 0.91
Gametocyte possibly expressed 0.34 0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1316800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.811 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1415300)

  • Relative Growth Rate: 0.11 ± 0.19
  • Confidence: 4.70

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K9E7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_166337

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 8 14 29
disruptive 4 33 22 54
missense 4 32 22 48

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 29 27 16
disruptive 11 71 22 81
missense 7 68 20 69

PlasmoDB Total SNPs: 170

Non-coding: 142 | Synonymous: 20 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 290 | Molecular Weight (kDa): 34.492

UniProt ID(s): A0A5K1K9E7

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005606 Sec20
PFam PF03908 Sec20
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11477110 The yeast SEC20 gene is required for N- and O-glycosylation in the Golgi.Evidence that impaired glycosylation does not correlate with the secretorydefect Schleip I, Heiss E, Lehle L 10.1074/jbc.M103753200
11739780 Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, acomponent of the ER target site that interacts with a COPI coat subunit Reilly BA, Kraynack BA, VanRheenen SM, Waters MG 10.1091/mbc.12.12.3783
24152736 ER-associated SNAREs and Sey1p mediate nuclear fusion at two distinct stepsduring yeast mating Rogers JV, Arlow T, ..., Rose MD 10.1091/mbc.E13-08-0441
11493604 The coatomer-interacting protein Dsl1p is required for Golgi-to-endoplasmicreticulum retrieval in yeast Andag U, Neumann T, Schmitt HD 10.1074/jbc.M105833200
11114899 Divergence of eukaryotic secretory components: the Candida albicans homolog ofthe Saccharomyces cerevisiae ++Sec20 protein is N terminally truncated, and itslevels determine antifungal drug resistance and growth Weber Y, Santore UJ, Ernst JF, Swoboda RK 10.1128/JB.183.1.46-54.2001
26216899 SNAREs support atlastin-mediated homotypic ER fusion in Saccharomyces cerevisiae Lee M, Ko YJ, ..., Jun Y 10.1083/jcb.201501043