PF3D7_1316900

Genome location: Pf3D7_13_v3:700,380..707,545(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0032777	Piccolo NuA4 histone acetyltransferase complex
Component	GO:0005634	nucleus
Process	GO:0006357	regulation of transcription by RNA polymerase II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.56	0.73
Trophozoite	expressed	0.68	0.62
Schizont	expressed	0.44	0.72
Gametocyte	possibly expressed	0.58	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1316900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.034 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1415400)

Relative Growth Rate: 0.15 ± 0.13
Confidence: 5.48

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5C0

"Best" AlphaFill ligand hit: DCP (2'-deoxycytidine-5'-triphosphate, Local RMSD=0.70) with 2JAQ (Global RMSD=23.90)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132978

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	1	0
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	singleton
synonymous	1	0
disruptive	0	1
missense	0	0

PlasmoDB Total SNPs: 309

Non-coding: 219 | Synonymous: 55 | Nonsynonymous: 33 | Stop Codon: 2

Protein Information

Protein Length: 958 | Molecular Weight (kDa): 114.274

UniProt ID(s): C0H5C0

PDB ID(s): None

Isoelectric Point: 8.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR024943	Enhancer of polycomb protein
PFam	N/A	N/A
Superfamily	N/A	N/A