PF3D7_1317000 (USP39)

Genome location: Pf3D7_13_v3:707,799..710,556(+)

Genome classification: Core

Function and Localization

Product Description: U4/U6.U5 tri-snRNP-associated protein 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0000398	mRNA splicing, via spliceosome
Process	GO:0000245	spliceosomal complex assembly
Process	GO:0006511	ubiquitin-dependent protein catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.30	0.85
Trophozoite	possibly expressed	0.62	0.65
Schizont	not expressed	0.32	0.79
Gametocyte	not expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.931 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I6Z8

"Best" AlphaFill ligand hit: AYE (allylamine, Local RMSD=0.71) with 5L8W (Global RMSD=1.89)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102786

Most Similar Human Ortholog: A0A087X1B2

TM-align score: 0.86 | RMSD: 2.36

Seq Identity: 0.46 | Length: 446 / 640

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000168883	ubiquitin specific peptidase 39

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	36	13	41
disruptive	7	78	37	102
missense	4	60	31	75

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	71	27	41
disruptive	32	187	85	209
missense	16	127	63	116

PlasmoDB Total SNPs: 89

Non-coding: 44 | Synonymous: 30 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 640 | Molecular Weight (kDa): 74.636

UniProt ID(s): Q8I6Z8

PDB ID(s): None

Isoelectric Point: 7.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
InterPro	IPR001607	Zinc finger, UBP-type
InterPro	IPR033809	USP39
InterPro	IPR038765	Papain-like cysteine peptidase superfamily
PFam	PF00443	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
PFam	PF02148	Zinc finger, UBP-type
Superfamily	SSF54001	Papain-like cysteine peptidase superfamily
Superfamily	SSF57850