PF3D7_1317300

Genome location: Pf3D7_13_v3:730,266..732,727(-)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.30	0.86
Trophozoite	expressed	1.04	0.46
Schizont	expressed	0.31	0.81
Gametocyte	expressed	0.64	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.689 | MFS: -2.912 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1415800)

Relative Growth Rate: 0.05 ± 0.11
Confidence: 5.78

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8R1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533546

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	6	21
disruptive	3	31	8	46
missense	3	29	8	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	30	15	16
disruptive	9	69	40	74
missense	3	62	32	57

PlasmoDB Total SNPs: 104

Non-coding: 90 | Synonymous: 12 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 296 | Molecular Weight (kDa): 34.863

UniProt ID(s): A0A5K1K8R1

PDB ID(s): None

Isoelectric Point: 5.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035979	RNA-binding domain superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily