PF3D7_1317400

Genome location: Pf3D7_13_v3:732,710..734,063(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0034399	nuclear periphery
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.22	0.90
Trophozoite	expressed	0.93	0.51
Schizont	expressed	0.19	0.88
Gametocyte	expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -2.87 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1415900)

Relative Growth Rate: 0.85 ± 0.16
Confidence: 5.01

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1415900)

Modification: Disrupted | RMgm-3817

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K928

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533731

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	7	2	12
disruptive	8	28	13	46
missense	8	25	13	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	18	13	13
disruptive	21	73	30	57
missense	12	67	24	41

PlasmoDB Total SNPs: 84

Non-coding: 60 | Synonymous: 13 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 205 | Molecular Weight (kDa): 23.193

UniProt ID(s): A0A5K1K928

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001876	Zinc finger, RanBP2-type
InterPro	IPR036443	Zinc finger, RanBP2-type superfamily
PFam	N/A	N/A
Superfamily	SSF90209	Zinc finger, RanBP2-type superfamily

PMID	Title	Authors	DOI/Link
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
28288121	A genetic system to study Plasmodium falciparum protein function.	Birnbaum J, Flemming S, ..., Spielmann T	10.1038/nmeth.4223
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596