PF3D7_1317500

Genome location: Pf3D7_13_v3:734,604..734,999(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	possibly expressed	0.10	0.93
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.15	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: -2.276 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEE1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160747

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	1	8
disruptive	1	1	2	8
missense	1	1	2	7

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	14	3	10
disruptive	1	14	7	38
missense	1	7	7	24

PlasmoDB Total SNPs: 8

Non-coding: 2 | Synonymous: 6 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 89 | Molecular Weight (kDa): 10.46

UniProt ID(s): Q8IEE1

PDB ID(s): None

Isoelectric Point: 9.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A