PF3D7_1317600

Genome location: Pf3D7_13_v3:734,806..738,618(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.18	0.92
Trophozoite	expressed	0.46	0.72
Schizont	expressed	0.14	0.91
Gametocyte	expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.042 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1416100)

Relative Growth Rate: 0.09 ± 0.07
Confidence: 6.75

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5C1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533057

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	21	15	38
disruptive	17	82	44	102
missense	15	78	41	94

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	62	29	41
disruptive	29	169	76	187
missense	22	143	59	126

PlasmoDB Total SNPs: 210

Non-coding: 148 | Synonymous: 33 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 620 | Molecular Weight (kDa): 73.866

UniProt ID(s): C0H5C1

PDB ID(s): None

Isoelectric Point: 8.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A