PF3D7_1317700

Genome location: Pf3D7_13_v3:738,072..739,888(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.32	0.84
Trophozoite	no data	0.32	0.81
Schizont	no data	0.05	0.97
Gametocyte	no data	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.298 | MFS: -3.446 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1416200)

Relative Growth Rate: 0.10 ± 0.16
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IED9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532708

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	singleton
synonymous	0	1
disruptive	1	1
missense	0	0

Any inclusion in genotype call

variant type	common	singleton
synonymous	0	1
disruptive	1	1
missense	0	0

PlasmoDB Total SNPs: 123

Non-coding: 108 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 157 | Molecular Weight (kDa): 18.735

UniProt ID(s): Q8IED9

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A