Product Description: 40S ribosomal protein S19
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000028 | ribosomal small subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.93 | 0.27 |
| Trophozoite | expressed | 2.03 | 0.20 |
| Schizont | expressed | 0.56 | 0.68 |
| Gametocyte | expressed | 1.01 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1317800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.133 | MFS: -2.762 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H5C2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100373
Most Similar Human Ortholog: S4R456
TM-align score: 0.97 | RMSD: 0.56
Seq Identity: 0.57 | Length: 68 / 145
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115268 | ribosomal protein S15 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 9 | 4 | 11 |
| disruptive | 1 | 2 | 3 | 6 |
| missense | 1 | 2 | 3 | 4 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 18 | 6 | 11 |
| disruptive | 3 | 7 | 11 | 38 |
| missense | 2 | 5 | 8 | 27 |
PlasmoDB Total SNPs: 101
Non-coding: 98 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 145 | Molecular Weight (kDa): 16.764
UniProt ID(s): C0H5C2
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 10.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002222 | Ribosomal protein S19/S15 |
| InterPro | IPR005713 | Ribosomal protein S19A/S15e |
| InterPro | IPR020934 | Ribosomal protein S19 conserved site |
| InterPro | IPR023575 | Ribosomal protein S19, superfamily |
| PFam | PF00203 | Ribosomal protein S19/S15 |
| Superfamily | SSF54570 | Ribosomal protein S19, superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |