PF3D7_1317900 (NOC4)

Genome location: Pf3D7_13_v3:741,709..745,151(-)

Genome classification: Core

Function and Localization

Product Description: nucleolar complex protein 4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030692	Noc4p-Nop14p complex
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Process	GO:0042254	ribosome biogenesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.88	0.61
Trophozoite	expressed	0.40	0.78
Schizont	expressed	0.13	0.92
Gametocyte	expressed	0.41	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1317900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.009 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1416400)

Relative Growth Rate: 0.23 ± 0.12
Confidence: 5.61

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1416400)

Modification: Disrupted | RMgm-3818

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IED7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533331

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	44	34	67
disruptive	34	172	109	246
missense	19	131	92	207

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	98	42	75
disruptive	76	382	183	313
missense	41	292	147	233

PlasmoDB Total SNPs: 167

Non-coding: 56 | Synonymous: 47 | Nonsynonymous: 62 | Stop Codon: 2

Protein Information

Protein Length: 974 | Molecular Weight (kDa): 116.03

UniProt ID(s): Q8IED7

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005612	CCAAT-binding factor
InterPro	IPR027193	Nucleolar complex protein 4
PFam	PF03914	CCAAT-binding factor
Superfamily	N/A	N/A