About Gene List

PF3D7_1318000

Genome location: Pf3D7_13_v3:745,720..747,765(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.03 0.99
Trophozoite possibly expressed 0.02 0.99
Schizont expressed 1.00 0.49
Gametocyte expressed 0.03 0.98

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.965 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IED6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_148529

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 12 3 20
disruptive 0 13 13 35
missense 0 13 13 29

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 26 5 18
disruptive 2 43 20 63
missense 1 37 18 44

PlasmoDB Total SNPs: 165

Non-coding: 158 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 192 | Molecular Weight (kDa): 22.051

UniProt ID(s): Q8IED6

PDB ID(s): None

Isoelectric Point: 9.05

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597