Product Description: ferredoxin
SignalP Peptide: MNIVILLLILTFSIKHSNT
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Function | GO:0009055 | electron transfer activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.21 | 0.86 |
| Schizont | not expressed | 0.07 | 0.95 |
| Gametocyte | not expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1318100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.659 | MFS: -2.447 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1416600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IED5
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.13) with 6XTF (Global RMSD=0.48)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 8 | 4 | 12 |
| disruptive | 6 | 11 | 5 | 15 |
| missense | 6 | 11 | 5 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 10 | 12 |
| disruptive | 11 | 29 | 15 | 49 |
| missense | 9 | 23 | 12 | 23 |
PlasmoDB Total SNPs: 54
Non-coding: 45 | Synonymous: 5 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 194 | Molecular Weight (kDa): 22.721
UniProt ID(s): A0A5J6C0F6, A0A5J6C0G5, A0A5J6C0K8, A0A5J6C0V9, A0A5J6C189, A0A5J6C1C0, A0A5J6C2A8, A0A5J6C2G4, A0A5J6C2P7, A0A5J6C2R7, A0A5J6C3A5, A0A5J6C3M4, Q8IED5
PDB ID(s): 1IUE
Isoelectric Point: 7.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| InterPro | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| InterPro | IPR010241 | Ferredoxin [2Fe-2S], plant |
| InterPro | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
| PFam | PF00111 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Superfamily | SSF54292 | 2Fe-2S ferredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 17251200 | Cloning and characterization of ferredoxin and ferredoxin-NADP+ reductase fromhuman malaria parasite. | Kimata-Ariga Y, Kurisu G, ..., Hase T | 10.1093/jb/mvm046 |
| 29688515 | Plasmodium-specific basic amino acid residues important for the interaction withferredoxin on the surface of ferredoxin-NADP+ reductase. | Kimata-Ariga Y, Yuasa S, ..., Hase T | 10.1093/jb/mvy045 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |