PF3D7_1318300

Genome location: Pf3D7_13_v3:752,413..759,638(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.22	0.90
Trophozoite	expressed	0.76	0.60
Schizont	possibly expressed	0.28	0.83
Gametocyte	expressed	0.99	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318300

Resistome Missense Mutations: D905N

Resistome Compounds with Missense Mutations: Proguanil

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.788 | MFS: -2.316 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IED3

"Best" AlphaFill ligand hit: HCY ((11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Local RMSD=5.49) with 2V95 (Global RMSD=37.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532811

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	74	44	119
disruptive	101	304	161	429
missense	64	268	150	369

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	40	149	76	137
disruptive	164	599	278	557
missense	106	515	235	415

PlasmoDB Total SNPs: 393

Non-coding: 82 | Synonymous: 142 | Nonsynonymous: 169 | Stop Codon: 0

Protein Information

Protein Length: 1840 | Molecular Weight (kDa): 214.846

UniProt ID(s): Q8IED3

PDB ID(s): None

Isoelectric Point: 4.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A