Product Description: structural maintenance of chromosomes protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000775 | chromosome, centromeric region |
| Component | GO:0000796 | condensin complex |
| Component | GO:0005634 | nucleus |
| Process | GO:0007076 | mitotic chromosome condensation |
| Process | GO:0000070 | mitotic sister chromatid segregation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.15 | 0.93 |
| Trophozoite | expressed | 1.06 | 0.48 |
| Schizont | expressed | 0.72 | 0.62 |
| Gametocyte | expressed | 0.82 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1318400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.676 | MFS: -3.193 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1416900)
Modification: Mutated | RMgm-4753
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IED2
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=0.04) with 5H67 (Global RMSD=3.69)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101492
Most Similar Human Ortholog: A0A0C4DGE5
TM-align score: 0.64 | RMSD: 3.18
Seq Identity: 0.40 | Length: 130 / 1218
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136824 | structural maintenance of chromosomes 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 51 | 33 | 67 |
| disruptive | 6 | 41 | 28 | 86 |
| missense | 6 | 40 | 28 | 79 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 97 | 40 | 95 |
| disruptive | 19 | 107 | 73 | 174 |
| missense | 13 | 84 | 65 | 144 |
PlasmoDB Total SNPs: 217
Non-coding: 170 | Synonymous: 39 | Nonsynonymous: 8 | Stop Codon: 0
Protein Length: 1218 | Molecular Weight (kDa): 143.059
UniProt ID(s): Q8IED2
PDB ID(s): None
Isoelectric Point: 8.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003395 | RecF/RecN/SMC, N-terminal |
| InterPro | IPR010935 | SMCs flexible hinge |
| InterPro | IPR024704 | Structural maintenance of chromosomes protein |
| InterPro | IPR027120 | Smc2, ATP-binding cassette domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR036277 | SMCs flexible hinge superfamily |
| PFam | PF02463 | RecF/RecN/SMC, N-terminal |
| PFam | PF06470 | SMCs flexible hinge |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF57997 | SMCs flexible hinge superfamily |
| Superfamily | SSF75553 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 17653272 | Rapid identification of malaria vaccine candidates based on alpha-helical coiledcoil protein motif. | Villard V, Agak GW, ..., Corradin G | 10.1371/journal.pone.0000645 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32049018 | Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and AreEssential for Parasite Proliferation and Transmission. | Pandey R, Abel S, ..., Tewari R | 10.1016/j.celrep.2020.01.033 |
| 34723504 | Ycs4 Subunit of Saccharomyces cerevisiae Condensin Binds DNA and Modulates theEnzyme Turnover | Sarkar R, Petrushenko ZM, Dawson DS, Rybenkov VV | 10.1021/acs.biochem.1c00473 |