PF3D7_1318500

Genome location: Pf3D7_13_v3:765,769..767,774(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.01	1.00
Trophozoite	no data	0.03	0.98
Schizont	no data	0.03	0.98
Gametocyte	no data	0.76	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.986 | MFS: -1.724 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1417000)

Relative Growth Rate: 1.10 ± 0.19
Confidence: 4.69

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1417000)

Modification: Disrupted | RMgm-3820

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5C3

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.04) with 4W8F (Global RMSD=18.59)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104624

Most Similar Human Ortholog: A0A7P0TBD3

TM-align score: 0.90 | RMSD: 1.49

Seq Identity: 0.09 | Length: 124 / 228

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000100014	sperm antigen with calponin homology and coiled-coil domains 1 like
ENSG00000128487	sperm antigen with calponin homology and coiled-coil domains 1
ENSG00000258555	SPECC1L-ADORA2A readthrough (NMD candidate)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	9	4	13
disruptive	4	20	11	30
missense	4	20	11	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	14	7	15
disruptive	12	34	22	46
missense	10	32	19	31

PlasmoDB Total SNPs: 77

Non-coding: 60 | Synonymous: 9 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 228 | Molecular Weight (kDa): 27.66

UniProt ID(s): C0H5C3

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A