PF3D7_1318600

Genome location: Pf3D7_13_v3:768,049..769,846(+)

Genome classification: Core

Function and Localization

Product Description: thioredoxin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.15	0.90
Schizont	not expressed	0.07	0.95
Gametocyte	not expressed	0.23	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.191 | MFS: -3.301 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5C4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_150866

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	24	17	26
disruptive	6	51	26	66
missense	6	51	25	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	45	22	28
disruptive	17	93	62	111
missense	14	88	57	95

PlasmoDB Total SNPs: 40

Non-coding: 10 | Synonymous: 16 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 533 | Molecular Weight (kDa): 63.616

UniProt ID(s): C0H5C4

PDB ID(s): None

Isoelectric Point: 9.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013766	Thioredoxin domain
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF00085	Thioredoxin domain
Superfamily	SSF52833	Thioredoxin-like superfamily