About Gene List

PF3D7_1318700 (AAP4)

Genome location: Pf3D7_13_v3:770,473..772,913(-)

Genome classification: Core

Function and Localization

Product Description: protein AAP4

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045177 apical part of cell
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.17 0.91
Trophozoite not expressed 0.06 0.97
Schizont expressed 0.92 0.63
Gametocyte expressed 0.99 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: 0.238 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEC9

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=1.63) with 3A4L (Global RMSD=23.66)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133955

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 32 25 51
disruptive 13 72 58 113
missense 13 72 57 101

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 70 31 59
disruptive 23 167 82 134
missense 20 154 79 120

PlasmoDB Total SNPs: 66

Non-coding: 33 | Synonymous: 15 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 749 | Molecular Weight (kDa): 88.574

UniProt ID(s): Q8IEC9

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341
31470470 The apical annuli of Toxoplasma gondii are composed of coiled-coil and signallingproteins embedded in the inner membrane complex sutures Engelberg K, Chen CT, ..., Gubbels MJ 10.1111/cmi.13112
27506886 Antioxidant activity in vitro and in vivo of the polysaccharides from differentvarieties of Auricularia auricula Xu S, Zhang Y, Jiang K 10.1039/c6fo00686h