PF3D7_1318900

Genome location: Pf3D7_13_v3:778,097..781,679(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.16	0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1318900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.781 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEC7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533701

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	32	15	35
disruptive	16	84	48	101
missense	16	84	46	97

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	56	20	42
disruptive	30	181	80	162
missense	27	159	73	133

PlasmoDB Total SNPs: 214

Non-coding: 147 | Synonymous: 30 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 581 | Molecular Weight (kDa): 69.241

UniProt ID(s): Q8IEC7

PDB ID(s): None

Isoelectric Point: 8.81

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A