PF3D7_1319000

Genome location: Pf3D7_13_v3:783,752..788,197(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	possibly expressed	0.11	0.93
Schizont	not expressed	0.04	0.97
Gametocyte	expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319000

Resistome Missense Mutations: P573S

Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.215 | MFS: -2.523 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0524300)

Relative Growth Rate: 0.57 ± 0.19
Confidence: 4.74

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEC6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145873

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	40	55	20	54
disruptive	75	158	70	193
missense	45	101	49	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	50	94	43	67
disruptive	119	294	154	298
missense	65	212	113	180

PlasmoDB Total SNPs: 361

Non-coding: 131 | Synonymous: 140 | Nonsynonymous: 90 | Stop Codon: 0

Protein Information

Protein Length: 960 | Molecular Weight (kDa): 113.379

UniProt ID(s): Q8IEC6

PDB ID(s): None

Isoelectric Point: 6.48

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A