PF3D7_1319200

Genome location: Pf3D7_13_v3:792,381..795,633(-)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.09	0.95
Trophozoite	not expressed	0.08	0.96
Schizont	not expressed	0.04	0.98
Gametocyte	possibly expressed	0.67	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.241 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1417700)

Modification: Disrupted | RMgm-4295

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEC4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_116261

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	38	28	50
disruptive	17	94	74	178
missense	12	86	69	170

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	83	46	56
disruptive	31	259	119	234
missense	21	230	109	187

PlasmoDB Total SNPs: 133

Non-coding: 34 | Synonymous: 72 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 868 | Molecular Weight (kDa): 103.851

UniProt ID(s): Q8IEC4

PDB ID(s): None

Isoelectric Point: 6.77

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011714	Seven residue repeat
InterPro	IPR011990	Tetratricopeptide-like helical domain superfamily
PFam	PF07709	Seven residue repeat
Superfamily	SSF48452	Tetratricopeptide-like helical domain superfamily
Superfamily	SSF58104