About Gene List

PF3D7_1319400

Genome location: Pf3D7_13_v3:800,542..806,858(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.44 0.80
Trophozoite expressed 1.77 0.29
Schizont expressed 1.37 0.43
Gametocyte expressed 1.65 0.28

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319400

Resistome Missense Mutations: D328Y

Resistome Compounds with Missense Mutations: MMV665794

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -2.942 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1417900)

  • Relative Growth Rate: 0.07 ± 0.07
  • Confidence: 6.74

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K826

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.57) with 6JWW (Global RMSD=48.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146143

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 53 24 56
disruptive 18 65 47 115
missense 14 57 42 94

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 93 49 75
disruptive 40 191 89 282
missense 20 151 71 204

PlasmoDB Total SNPs: 327

Non-coding: 281 | Synonymous: 33 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 1070 | Molecular Weight (kDa): 127.67

UniProt ID(s): A0A5K1K826, Q86FQ3

PDB ID(s): None

Isoelectric Point: 7.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108