PF3D7_1319500

Genome location: Pf3D7_13_v3:806,869..807,443(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.00	1.00
Gametocyte	not expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.581 | MFS: -3.153 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1418000)

Relative Growth Rate: 0.13 ± 0.10
Confidence: 5.93

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEC1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_149561

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	6	5	5
disruptive	1	7	3	10
missense	1	7	3	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	14	6	5
disruptive	2	15	9	25
missense	1	13	8	17

PlasmoDB Total SNPs: 13

Non-coding: 12 | Synonymous: 0 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 74 | Molecular Weight (kDa): 9.002

UniProt ID(s): Q8IEC1

PDB ID(s): None

Isoelectric Point: 10.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A