PF3D7_1319600

Genome location: Pf3D7_13_v3:808,286..815,634(+)

Genome classification: Core

Function and Localization

Product Description: female development protein FD3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.11	0.94
Schizont	not expressed	0.26	0.84
Gametocyte	expressed	1.49	0.35

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.67 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1418100)

Modification: Tagged | RMgm-5256

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8F4

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.04) with 6JWR (Global RMSD=13.52)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532902

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	76	36	114
disruptive	26	212	157	315
missense	21	198	153	280

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	157	71	131
disruptive	82	535	220	470
missense	50	474	186	323

PlasmoDB Total SNPs: 383

Non-coding: 208 | Synonymous: 93 | Nonsynonymous: 82 | Stop Codon: 0

Protein Information

Protein Length: 1633 | Molecular Weight (kDa): 193.855

UniProt ID(s): A0A5K1K8F4

PDB ID(s): None

Isoelectric Point: 7.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR028078	AP2-coincident, C-terminal domain
PFam	PF14733	AP2-coincident, C-terminal domain
Superfamily	N/A	N/A