PF3D7_1319700

Genome location: Pf3D7_13_v3:815,505..818,847(-)

Genome classification: Core

Function and Localization

Product Description: protein phosphatase PP2A regulatory subunit A, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0000159	protein phosphatase type 2A complex
Component	GO:0008287	protein serine/threonine phosphatase complex
Function	GO:0019888	protein phosphatase regulator activity
Function	GO:0004722	protein serine/threonine phosphatase activity
Process	GO:0006417	regulation of translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.31	0.80
Schizont	not expressed	0.12	0.92
Gametocyte	expressed	0.35	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.183 | MFS: -2.838 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEB9

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.1.3.16	protein-serine/threonine phosphatase	ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101100

Most Similar Human Ortholog: C9J9C1

TM-align score: 0.76 | RMSD: 2.56

Seq Identity: 0.20 | Length: 334 / 858

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000105568	protein phosphatase 2 scaffold subunit Aalpha
ENSG00000137713	protein phosphatase 2 scaffold subunit Abeta

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	49	17	42
disruptive	9	51	23	108
missense	6	49	22	88

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	17	81	30	65
disruptive	16	138	64	220
missense	9	113	52	149

PlasmoDB Total SNPs: 114

Non-coding: 70 | Synonymous: 25 | Nonsynonymous: 18 | Stop Codon: 1

Protein Information

Protein Length: 858 | Molecular Weight (kDa): 102.358

UniProt ID(s): Q8IEB9

PDB ID(s): None

Isoelectric Point: 5.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold