PF3D7_1319900

Genome location: Pf3D7_13_v3:822,078..826,547(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MYNMNIPLIITILLFLFYQHYVCS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	not expressed	0.17	0.90
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1319900

Resistome Missense Mutations: K1396Q

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.315 | #Insertions: 10

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEB7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532810

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	64	28	81
disruptive	46	138	105	218
missense	39	115	101	193

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	116	54	83
disruptive	80	324	158	303
missense	61	268	136	219

PlasmoDB Total SNPs: 154

Non-coding: 0 | Synonymous: 75 | Nonsynonymous: 79 | Stop Codon: 0

Protein Information

Protein Length: 1489 | Molecular Weight (kDa): 178.96

UniProt ID(s): Q8IEB7

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A