About Gene List

PF3D7_1320000 (GP1)

Genome location: Pf3D7_13_v3:828,978..834,253(+)

Genome classification: Core

Function and Localization

Product Description: golgi protein 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005794 Golgi apparatus
Component GO:0005737 cytoplasm
Component GO:0005783 endoplasmic reticulum
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.33 0.43
Trophozoite expressed 0.79 0.58
Schizont expressed 0.90 0.51
Gametocyte expressed 0.51 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1320000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.864 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1418300)

Modification: Tagged | RMgm-215

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Q9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532615

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 58 38 80
disruptive 30 128 84 192
missense 22 120 82 170

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 124 56 91
disruptive 55 297 148 332
missense 39 258 129 234

PlasmoDB Total SNPs: 205

Non-coding: 119 | Synonymous: 55 | Nonsynonymous: 30 | Stop Codon: 1

Protein Information

Protein Length: 1258 | Molecular Weight (kDa): 149.18

UniProt ID(s): A0A5K1K8Q9

PDB ID(s): None

Isoelectric Point: 6.86

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
19428669 Localisation and timing of expression of putative Plasmodium berghei rhoptryproteins in merozoites and sporozoites. Tufet-Bayona M, Janse CJ, ..., Franke-Fayard B 10.1016/j.molbiopara.2009.02.009
26375591 Evidence that the Malaria Parasite Plasmodium falciparum Putative Rhoptry Protein2 Localizes to the Golgi Apparatus throughout the Erythrocytic Cycle. Hallee S, Richard D 10.1371/journal.pone.0138626
29579782 Identification of a Golgi apparatus protein complex important for the asexualerythrocytic cycle of the malaria parasite Plasmodium falciparum. Hallee S, Theriault C, ..., Richard D 10.1111/cmi.12843