PF3D7_1320300

Genome location: Pf3D7_13_v3:838,739..840,965(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	possibly expressed	0.20	0.87
Schizont	possibly expressed	0.09	0.94
Gametocyte	not expressed	0.12	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1320300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.169 | #Insertions: 4

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1418600)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.19

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1418600)

Modification: Disrupted | RMgm-3828

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8T8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_137492

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	31	18	40
disruptive	10	60	45	92
missense	9	59	42	84

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	67	19	41
disruptive	25	148	70	169
missense	16	125	60	117

PlasmoDB Total SNPs: 93

Non-coding: 46 | Synonymous: 29 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 705 | Molecular Weight (kDa): 85.183

UniProt ID(s): A0A5K1K8T8

PDB ID(s): None

Isoelectric Point: 9.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A