Product Description: type I signal peptidase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.21.89 (Signal peptidase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0016234 | inclusion body |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0009056 | catabolic process |
| Process | GO:0006465 | signal peptide processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.95 |
| Trophozoite | expressed | 0.63 | 0.64 |
| Schizont | not expressed | 0.09 | 0.94 |
| Gametocyte | not expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1320400
Resistome Missense Mutations: I276M
Resistome Compounds with Missense Mutations: BI-2536
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.975 | MFS: -2.576 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K8B7
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.21.89 | Signal peptidase I | NEMSDSEDTAMG132cholateantipainL685,458rifampicinBAL0019193arylomycinlactacystindeoxycholate... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P00803 | Signal peptidase I | Escherichia coli | OrthoMCL | CHEMBL4283678CHEMBL4288133CHEMBL4291944CHEMBL4284736... |
Ortholog Group (OrthoMCL): OG6_100609
Most Similar Human Ortholog: Q96LU5
TM-align score: 0.74 | RMSD: 2.74
Seq Identity: 0.31 | Length: 147 / 359
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148950 | inner mitochondrial membrane peptidase subunit 1 |
Protein Length: 359 | Molecular Weight (kDa): 43.387
UniProt ID(s): A0A5K1K8B7, Q6PSM5, Q6PSM6
PDB ID(s): None
Isoelectric Point: 10.23
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000223 | Peptidase S26A, signal peptidase I |
| InterPro | IPR019533 | Peptidase S26 |
| InterPro | IPR019758 | Peptidase S26A, signal peptidase I, conserved site |
| InterPro | IPR036286 | LexA/Signal peptidase-like superfamily |
| PFam | PF10502 | Peptidase S26 |
| Superfamily | SSF51306 | LexA/Signal peptidase-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 19 | 15 | 25 |
| disruptive | 9 | 37 | 26 | 60 |
| missense | 6 | 34 | 23 | 52 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 43 | 15 | 24 |
| disruptive | 22 | 106 | 41 | 101 |
| missense | 11 | 81 | 32 | 69 |
PlasmoDB Total SNPs: 36
Non-coding: 23 | Synonymous: 7 | Nonsynonymous: 6 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16489263 | Isolation and characterization of type I signal peptidase of different malariaparasites. | Sharma S, Pradhan A, Chauhan VS, Tuteja R | 10.1155/JBB.2005.301 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |