PF3D7_1320500 (SNAP23)

Genome location: Pf3D7_13_v3:843,281..845,534(+)

Genome classification: Core

Function and Localization

Product Description: SNARE protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Component	GO:0005886	plasma membrane
Process	GO:0006886	intracellular protein transport
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.21	0.86
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.10	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1320500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.222 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5C6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106569

Most Similar Human Ortholog: O95721

TM-align score: 0.69 | RMSD: 2.23

Seq Identity: 0.18 | Length: 159 / 211

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000099940	synaptosome associated protein 29

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	14	4	9
disruptive	2	16	8	31
missense	2	16	7	31

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	17	8	16
disruptive	5	48	29	55
missense	3	41	22	41

PlasmoDB Total SNPs: 122

Non-coding: 115 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 211 | Molecular Weight (kDa): 25.016

UniProt ID(s): C0H5C6, Q0ZAF4

PDB ID(s): None

Isoelectric Point: 9.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000727	Target SNARE coiled-coil homology domain
PFam	N/A	N/A
Superfamily	SSF58038	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108