Product Description: ras-related protein Rab-11A
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.5.2 (Small monomeric GTPase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005768 | endosome |
| Component | GO:0020020 | food vacuole |
| Component | GO:0070258 | inner membrane pellicle complex |
| Component | GO:0016020 | membrane |
| Component | GO:0055037 | recycling endosome |
| Component | GO:0020008 | rhoptry |
| Function | GO:0005515 | protein binding |
| Process | GO:0007264 | small GTPase mediated signal transduction |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.83 |
| Trophozoite | expressed | 0.37 | 0.77 |
| Schizont | expressed | 0.37 | 0.78 |
| Gametocyte | expressed | 0.47 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1320600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.131 | MFS: -3.076 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1339500)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1418900)
Modification: Mutated | RMgm-4837
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q76NM4
"Best" AlphaFill ligand hit: GNP (phosphoaminophosphonic acid-guanylate ester, Local RMSD=0.06) with 3LAW (Global RMSD=2.23)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.5.2 | small monomeric GTPase | GTPGDPEDTAPlexAstatinCCG-977Rap1GapNSC23766CCG-1423Rap1GAP1GTPgammaSCalmodulin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100582
Most Similar Human Ortholog: M0R377
TM-align score: 0.96 | RMSD: 0.45
Seq Identity: 0.61 | Length: 46 / 216
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103769 | RAB11A, member RAS oncogene family |
| ENSG00000185236 | RAB11B, member RAS oncogene family |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 8 | 9 | 15 |
| disruptive | 0 | 3 | 1 | 10 |
| missense | 0 | 2 | 1 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 24 | 9 | 14 |
| disruptive | 3 | 12 | 20 | 48 |
| missense | 0 | 7 | 16 | 31 |
PlasmoDB Total SNPs: 161
Non-coding: 151 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 216 | Molecular Weight (kDa): 24.752
UniProt ID(s): Q25999, Q76NM4, Q9GPQ6
PDB ID(s): 3BFK
Isoelectric Point: 9.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001806 | Small GTPase |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00071 | Small GTPase |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 8682193 | Plasmodium falciparum: the small GTPase rab11. | Langsley G, Chakrabarti D | 10.1006/expr.1996.0071 |
| 12657463 | The Plasmodium falciparum family of Rab GTPases. | Quevillon E, Spielmann T, ..., Langsley G | 10.1016/s0378-1119(03)00381-0 |
| 19165333 | Rab11A-controlled assembly of the inner membrane complex is required forcompletion of apicomplexan cytokinesis. | Agop-Nersesian C, Naissant B, ..., Langsley G | 10.1371/journal.ppat.1000270 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 24284631 | Targeting Plasmodium PI(4)K to eliminate malaria. | McNamara CW, Lee MC, ..., Winzeler EA | 10.1038/nature12782 |