PF3D7_1320700

Genome location: Pf3D7_13_v3:849,130..854,321(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020007	apical complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.16	0.93
Trophozoite	expressed	0.58	0.70
Schizont	expressed	1.75	0.31
Gametocyte	expressed	0.91	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1320700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.036 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1419000)

Modification: Tagged | RMgm-4950

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEA7

"Best" AlphaFill ligand hit: PH2 (2-amino-6-hydroxymethyl-7,8-dihydro-3h-pteridin-4-one, Local RMSD=0.46) with 6JWU (Global RMSD=17.95)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130917

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	36	25	61
disruptive	52	99	49	174
missense	46	91	43	154

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	81	42	78
disruptive	84	229	122	268
missense	63	189	101	197

PlasmoDB Total SNPs: 174

Non-coding: 51 | Synonymous: 65 | Nonsynonymous: 57 | Stop Codon: 1

Protein Information

Protein Length: 1442 | Molecular Weight (kDa): 170.673

UniProt ID(s): Q8IEA7

PDB ID(s): None

Isoelectric Point: 9.18

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A