PF3D7_1321000

Genome location: Pf3D7_13_v3:859,299..861,347(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.03	0.99
Trophozoite	no data	0.03	0.98
Schizont	no data	0.06	0.96
Gametocyte	no data	0.78	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1321000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.136 | MFS: -3.155 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1419300)

Modification: Disrupted | RMgm-3830

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8Q7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533772

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	22	13	30
disruptive	14	60	38	84
missense	5	49	36	72

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	42	23	31
disruptive	28	123	75	121
missense	11	97	59	95

PlasmoDB Total SNPs: 33

Non-coding: 0 | Synonymous: 22 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 682 | Molecular Weight (kDa): 80.55

UniProt ID(s): A0A5K1K8Q7

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A