PF3D7_1321100

Genome location: Pf3D7_13_v3:861,001..872,925(-)

Genome classification: Core

Function and Localization

Product Description: protein kinase domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.18	0.91
Trophozoite	not expressed	0.31	0.84
Schizont	not expressed	3.06	0.15
Gametocyte	not expressed	0.22	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1321100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.69 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532330

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	94	48	121
disruptive	93	268	169	418
missense	66	216	139	344

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	39	157	88	163
disruptive	174	544	282	550
missense	108	421	238	403

PlasmoDB Total SNPs: 627

Non-coding: 102 | Synonymous: 265 | Nonsynonymous: 259 | Stop Codon: 1

Protein Information

Protein Length: 3447 | Molecular Weight (kDa): 405.102

UniProt ID(s): C0H5C8

PDB ID(s): None

Isoelectric Point: 6.99

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011009	Protein kinase-like domain superfamily
PFam	N/A	N/A
Superfamily	SSF56112	Protein kinase-like domain superfamily