About Gene List

PF3D7_1321200

Genome location: Pf3D7_13_v3:875,107..876,069(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.01 0.99
Trophozoite expressed 0.03 0.98
Schizont expressed 0.04 0.97
Gametocyte expressed 0.18 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1321200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.124 | MFS: -3.794 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IEA2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107357

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 3 2 5
disruptive 0 1 2 5
missense 0 1 1 5

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 10 2 5
disruptive 0 9 4 20
missense 0 6 3 14

PlasmoDB Total SNPs: 82

Non-coding: 79 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 78 | Molecular Weight (kDa): 8.816

UniProt ID(s): Q8IEA2

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR007513 Uncharacterised protein family SERF, N-terminal
InterPro IPR039438 At2g23090-like, zinc-binding domain
InterPro IPR039713 At2g23090-like
PFam PF04419 Uncharacterised protein family SERF, N-terminal
PFam PF12907 At2g23090-like, zinc-binding domain
Superfamily SSF118359 N/A

Associated Publications

No associated publications