PF3D7_1321300

Genome location: Pf3D7_13_v3:876,120..886,756(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.26	0.47
Trophozoite	expressed	1.38	0.36
Schizont	possibly expressed	0.70	0.66
Gametocyte	not expressed	0.71	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1321300

Resistome Missense Mutations: I1148K, I1154K, I1160K, I1166K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.393 | #Insertions: 17

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_192907

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	16	140	77	173
disruptive	93	442	278	664
missense	64	386	255	594

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	263	122	197
disruptive	200	944	431	803
missense	123	792	388	660

PlasmoDB Total SNPs: 294

Non-coding: 29 | Synonymous: 144 | Nonsynonymous: 121 | Stop Codon: 0

Protein Information

Protein Length: 3347 | Molecular Weight (kDa): 404.992

UniProt ID(s): Q8IEA1

PDB ID(s): None

Isoelectric Point: 8.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A