PF3D7_1321900

Genome location: Pf3D7_13_v3:910,812..913,627(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKVKKLVKFLSLLAVGLLS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0045177	apical part of cell

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.39	0.83
Trophozoite	expressed	0.16	0.90
Schizont	expressed	0.22	0.89
Gametocyte	not expressed	0.09	0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1321900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.534 | MFS: -3.11 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1337300)

Relative Growth Rate: 0.82 ± 0.08
Confidence: 6.46

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1337300)

Modification: Disrupted | RMgm-3578

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE97

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133072

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 154

Non-coding: 132 | Synonymous: 8 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 292 | Molecular Weight (kDa): 32.743

UniProt ID(s): Q8IE97

PDB ID(s): None

Isoelectric Point: 9.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A