About Gene List

PF3D7_1322200 (STU2)

Genome location: Pf3D7_13_v3:931,298..944,119(+)

Genome classification: Core

Function and Localization

Product Description: protein STU2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0000776 kinetochore
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.35 0.84
Trophozoite expressed 1.41 0.37
Schizont expressed 1.64 0.33
Gametocyte expressed 2.08 0.18

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1322200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.792 | MFS: -3.041 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533698

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 26 162 103 234
disruptive 119 360 220 541
missense 89 309 206 476

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 51 346 149 228
disruptive 203 789 362 795
missense 138 659 303 601

PlasmoDB Total SNPs: 544

Non-coding: 250 | Synonymous: 165 | Nonsynonymous: 129 | Stop Codon: 0

Protein Information

Protein Length: 3438 | Molecular Weight (kDa): 402.419

UniProt ID(s): A0A5K1K9E8

PDB ID(s): None

Isoelectric Point: 8.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016024 Armadillo-type fold
InterPro IPR034085 TOG domain
PFam N/A N/A
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36006241 Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation Brusini L, Dos Santos Pacheco N, ..., Brochet M 10.1083/jcb.202111084
33752231 Microtubule-associated proteins and motors required for ectopic microtubule arrayformation in Saccharomyces cerevisiae King BR, Meehl JB, ..., Davis TN 10.1093/genetics/iyab050
38305688 Kinetochore-microtubule error correction for biorientation: lessons from yeast Li S, Kasciukovic T, Tanaka TU 10.1042/BST20221261
33591274 Structural basis of Stu2 recruitment to yeast kinetochores Zahm JA, Stewart MG, ..., Miller MP 10.7554/eLife.65389
29779879 The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast Flor-Parra I, Iglesias-Romero AB, Chang F 10.1016/j.cub.2018.04.008