PF3D7_1322300

Genome location: Pf3D7_13_v3:944,138..949,434(-)

Genome classification: Core

Function and Localization

Product Description: BRCT domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	not expressed	0.92	0.53
Schizont	possibly expressed	0.16	0.90
Gametocyte	not expressed	1.04	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1322300

Resistome Missense Mutations: T473S

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.151 | MFS: -2.773 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1337600)

Relative Growth Rate: 0.10 ± 0.21
Confidence: 4.50

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8R9

"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=0.52) with 4KQB (Global RMSD=18.49)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532897

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	57	39	75
disruptive	48	141	83	175
missense	34	113	73	138

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	108	49	91
disruptive	95	285	147	300
missense	54	229	113	222

PlasmoDB Total SNPs: 212

Non-coding: 58 | Synonymous: 108 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 1499 | Molecular Weight (kDa): 178.348

UniProt ID(s): A0A5K1K8R9

PDB ID(s): None

Isoelectric Point: 6.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A