PF3D7_1322700

Genome location: Pf3D7_13_v3:958,097..959,380(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.08	0.95
Schizont	possibly expressed	0.02	0.98
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1322700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 1.001 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5D1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533032

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	13	7	15
disruptive	32	58	23	46
missense	12	37	13	29

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	27	10	17
disruptive	50	97	32	73
missense	24	52	25	52

PlasmoDB Total SNPs: 90

Non-coding: 42 | Synonymous: 31 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 318 | Molecular Weight (kDa): 37.322

UniProt ID(s): C0H5D1

PDB ID(s): None

Isoelectric Point: 4.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A