PF3D7_1322900

Genome location: Pf3D7_13_v3:961,213..963,561(+)

Genome classification: Core

Function and Localization

Product Description: CRYSP protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044312	crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.03	0.99
Trophozoite	expressed	0.07	0.96
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.78	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1322900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.222 | MFS: -2.718 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1338100)

Relative Growth Rate: 1.05 ± 0.18
Confidence: 4.80

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1338100)

Modification: Tagged | RMgm-5352

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H5D2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146126

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	11	5	19
disruptive	4	10	6	21
missense	4	10	6	19

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	22	11	23
disruptive	6	35	17	44
missense	4	31	16	37

PlasmoDB Total SNPs: 178

Non-coding: 158 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 263 | Molecular Weight (kDa): 30.454

UniProt ID(s): C0H5D2

PDB ID(s): None

Isoelectric Point: 6.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A