Product Description: 60S ribosomal protein L6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.28 | 0.48 |
| Trophozoite | expressed | 1.44 | 0.36 |
| Schizont | expressed | 0.34 | 0.79 |
| Gametocyte | expressed | 0.79 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1323100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.119 | MFS: -3 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1338300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IE85
"Best" AlphaFill ligand hit: C5P (cytidine-5'-monophosphate, Local RMSD=8.21) with 2ZWI (Global RMSD=15.99)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100791
Most Similar Human Ortholog: P32969
TM-align score: 0.99 | RMSD: 0.62
Seq Identity: 0.52 | Length: 190 / 190
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000163682 | ribosomal protein L9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 70
Non-coding: 65 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 190 | Molecular Weight (kDa): 21.602
UniProt ID(s): Q8IE85
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000702 | Ribosomal protein L6 |
| InterPro | IPR020040 | Ribosomal protein L6, alpha-beta domain |
| InterPro | IPR036789 | Ribosomal protein L6, alpha-beta domain superfamily |
| PFam | PF00347 | Ribosomal protein L6, alpha-beta domain |
| Superfamily | SSF56053 | Ribosomal protein L6, alpha-beta domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28288098 | Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit proteinsynthesis. | Wong W, Bai XC, ..., Baum J | 10.1038/nmicrobiol.2017.31 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |