About Gene List

PF3D7_1323400 (RPL23)

Genome location: Pf3D7_13_v3:971,388..973,888(-)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L23

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0019843 rRNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0000027 ribosomal large subunit assembly
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 1.60 0.38
Trophozoite expressed 1.91 0.23
Schizont expressed 0.41 0.76
Gametocyte not expressed 0.82 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1323400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.304 | MFS: -2.603 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE82

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100365

Most Similar Human Ortholog: K7EMA7

TM-align score: 0.97 | RMSD: 0.53

Seq Identity: 0.60 | Length: 70 / 190

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000198242 ribosomal protein L23a

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 164

Non-coding: 156 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 190 | Molecular Weight (kDa): 22.093

UniProt ID(s): Q8IE82

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001014 Ribosomal protein L23/L25, conserved site
InterPro IPR005633 Ribosomal protein L23/L25, N-terminal
InterPro IPR012678 Ribosomal protein L23/L15e core domain superfamily
InterPro IPR013025 Ribosomal protein L25/L23
PFam PF00276 Ribosomal protein L25/L23
PFam PF03939 Ribosomal protein L23/L25, N-terminal
Superfamily SSF54189 Ribosomal protein L23/L15e core domain superfamily

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
24913268 Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine Wong W, Bai XC, ..., Scheres SH 10.7554/eLife.03080
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596