PF3D7_1323600

Genome location: Pf3D7_13_v3:978,955..980,517(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.04	0.98
Trophozoite	expressed	0.34	0.78
Schizont	expressed	0.07	0.95
Gametocyte	expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1323600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.187 | MFS: -2.568 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1338800)

Relative Growth Rate: 0.10 ± 0.79
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE81

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156394

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	21	12	24
disruptive	1	13	17	49
missense	1	12	15	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	41	22	31
disruptive	8	45	50	86
missense	2	34	45	63

PlasmoDB Total SNPs: 45

Non-coding: 30 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 418 | Molecular Weight (kDa): 48.616

UniProt ID(s): Q8IE81

PDB ID(s): None

Isoelectric Point: 8.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A