PF3D7_1323800 (VPS52)

Genome location: Pf3D7_13_v3:984,290..988,964(-)

Genome classification: Core

Function and Localization

Product Description: vacuolar protein sorting-associated protein 52, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0006896	Golgi to vacuole transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.35	0.83
Trophozoite	possibly expressed	0.58	0.67
Schizont	possibly expressed	0.27	0.83
Gametocyte	possibly expressed	0.50	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1323800

Resistome Missense Mutations: I58K, K358N

Resistome Compounds with Missense Mutations: AN13762, Cipargamin/KAE609/NITD609

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.17 | MFS: -2.878 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8G8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101848

Most Similar Human Ortholog: A0A0G2JIG2

TM-align score: 0.85 | RMSD: 2.00

Seq Identity: 0.20 | Length: 123 / 1353

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000206286	VPS52 subunit of GARP complex
ENSG00000223501	VPS52 subunit of GARP complex
ENSG00000223618	VPS52 subunit of GARP complex
ENSG00000224455	VPS52 subunit of GARP complex
ENSG00000225590	VPS52 subunit of GARP complex
ENSG00000228425	VPS52 subunit of GARP complex
ENSG00000236014	VPS52 subunit of GARP complex

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	43	27	89
disruptive	49	207	92	247
missense	27	154	79	185

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	93	60	104
disruptive	105	367	189	351
missense	62	269	150	234

PlasmoDB Total SNPs: 246

Non-coding: 62 | Synonymous: 99 | Nonsynonymous: 85 | Stop Codon: 0

Protein Information

Protein Length: 1353 | Molecular Weight (kDa): 162.036

UniProt ID(s): A0A5K1K8G8

PDB ID(s): None

Isoelectric Point: 5.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007258	Vps52
PFam	PF04129	Vps52
Superfamily	N/A	N/A