PF3D7_1323900

Genome location: Pf3D7_13_v3:989,180..990,618(+)

Genome classification: Core

Function and Localization

Product Description: protein BCP1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.70	0.68
Trophozoite	expressed	0.69	0.61
Schizont	expressed	0.28	0.82
Gametocyte	expressed	0.64	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1323900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.739 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A5K1K8R6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102632

Most Similar Human Ortholog: Q9P287

TM-align score: 0.66 | RMSD: 3.05

Seq Identity: 0.15 | Length: 238 / 376

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107949	BRCA2 and CDKN1A interacting protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	12	22
disruptive	14	39	29	63
missense	9	29	21	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	34	23	19
disruptive	32	90	54	108
missense	13	67	43	83

PlasmoDB Total SNPs: 62

Non-coding: 21 | Synonymous: 31 | Nonsynonymous: 7 | Stop Codon: 3

Protein Information

Protein Length: 376 | Molecular Weight (kDa): 44.657

UniProt ID(s): A0A5K1K8R6

PDB ID(s): None

Isoelectric Point: 9.5

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025602	BCP1 family
PFam	PF13862	BCP1 family
Superfamily	N/A	N/A