PF3D7_1324000

Genome location: Pf3D7_13_v3:990,726..996,075(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.39	0.82
Trophozoite	expressed	0.47	0.74
Schizont	possibly expressed	0.35	0.80
Gametocyte	expressed	0.81	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1324000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.533 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE77

"Best" AlphaFill ligand hit: CLQ (n4-(7-chloro-quinolin-4-yl)-n1,n1-diethyl-pentane-1,4-diamine, Local RMSD=0.74) with 7DI7 (Global RMSD=27.64)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102544

Most Similar Human Ortholog: C9IYZ1

TM-align score: 0.72 | RMSD: 3.81

Seq Identity: 0.21 | Length: 502 / 1459

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000138381	asparagine synthetase domain containing 1
ENSG00000286165	novel protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	46	34	73
disruptive	69	222	118	283
missense	27	168	103	231

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	108	50	86
disruptive	131	438	183	341
missense	56	335	151	259

PlasmoDB Total SNPs: 286

Non-coding: 67 | Synonymous: 123 | Nonsynonymous: 96 | Stop Codon: 0

Protein Information

Protein Length: 1459 | Molecular Weight (kDa): 176.842

UniProt ID(s): Q8IE77

PDB ID(s): None

Isoelectric Point: 8.15

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF52402	N/A