PF3D7_1324100

Genome location: Pf3D7_13_v3:996,864..999,493(+)

Genome classification: Core

Function and Localization

Product Description: cyclin-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.52	0.69
Schizont	expressed	0.51	0.69
Gametocyte	not expressed	0.28	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1324100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.898 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1339300)

Relative Growth Rate: 0.82 ± 0.43
Confidence: 3.06

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1339300)

Modification: Disrupted | RMgm-3588

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE76

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533767

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	22	12	27
disruptive	0	17	10	38
missense	0	15	9	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	45	18	32
disruptive	7	54	32	88
missense	4	37	20	60

PlasmoDB Total SNPs: 93

Non-coding: 86 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 513 | Molecular Weight (kDa): 61.551

UniProt ID(s): Q8IE76

PDB ID(s): None

Isoelectric Point: 8.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036915	Cyclin-like superfamily
PFam	N/A	N/A
Superfamily	SSF47954	Cyclin-like superfamily