PF3D7_1324200

Genome location: Pf3D7_13_v3:999,535..1,001,981(-)

Genome classification: Core

Function and Localization

Product Description: micro-fibrillar-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005684	U2-type spliceosomal complex
Component	GO:0031012	extracellular matrix
Function	GO:0005201	extracellular matrix structural constituent
Process	GO:0000398	mRNA splicing, via spliceosome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.44	0.79
Trophozoite	expressed	0.59	0.66
Schizont	expressed	0.16	0.90
Gametocyte	expressed	0.45	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1324200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.603 | MFS: -2.402 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IE75

"Best" AlphaFill ligand hit: ACP (adenosine-5'-[beta, gamma-methylene]triphosphate, Local RMSD=0.03) with 2HCB (Global RMSD=23.36)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103001

Most Similar Human Ortholog: P55081

TM-align score: 0.27 | RMSD: 5.52

Seq Identity: 0.32 | Length: 163 / 492

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000140259	microfibril associated protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	27	15	25
disruptive	35	98	61	108
missense	17	63	35	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	46	25	30
disruptive	64	177	72	127
missense	30	113	45	72

PlasmoDB Total SNPs: 150

Non-coding: 75 | Synonymous: 41 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 492 | Molecular Weight (kDa): 59.628

UniProt ID(s): Q8IE75

PDB ID(s): None

Isoelectric Point: 4.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009730	Micro-fibrillar-associated protein 1, C-terminal
InterPro	IPR033194	Microfibrillar-associated protein 1
PFam	PF06991	Micro-fibrillar-associated protein 1, C-terminal
Superfamily	N/A	N/A